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You can catch Grand Canyon bus tours all over Las Vegas. Some tour operators will pick you up and drop you off at your hotel. Some bus tours also operate out of Boulder City and North Las Vegas, too.
If you want to fly into the canyon, most tour airlines operate planes and helicopters out of Las Vegas, and will combine your flight with a Grand Canyon bus tour once you arrive at the Grand Canyon Airport.
You can also get Grand Canyon bus tours to Williams, and then switch to the Grand Canyon Railway for your final journey to the canyon. If you would like to see more of Northern Arizona, combine Grand Canyon bus tours with tours to Sedona, Flagstaff, the Navajo country, or Lake Powell.